Cardiovascular changes during maturation and ageing in male and female spontaneously hypertensive rats

Chan, Vincent, Fenning, Andrew, Levick, Scott P., Loch, David, Chunduri, Prasad, Iyer, Abishek, Teo, Yi Ling, Hoey, Andrew, Wilson, Kathleen, Burstow, Darryl and Brown, Lindsay (2011) Cardiovascular changes during maturation and ageing in male and female spontaneously hypertensive rats. Journal of Cardiovascular Pharmacology, 57 4: 469-478. doi:10.1097/FJC.0b013e3182102c3b

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Author Chan, Vincent
Fenning, Andrew
Levick, Scott P.
Loch, David
Chunduri, Prasad
Iyer, Abishek
Teo, Yi Ling
Hoey, Andrew
Wilson, Kathleen
Burstow, Darryl
Brown, Lindsay
Title Cardiovascular changes during maturation and ageing in male and female spontaneously hypertensive rats
Journal name Journal of Cardiovascular Pharmacology   Check publisher's open access policy
ISSN 0160-2446
Publication date 2011-04
Sub-type Article (original research)
DOI 10.1097/FJC.0b013e3182102c3b
Volume 57
Issue 4
Start page 469
End page 478
Total pages 10
Place of publication Philadelphia, PA, United States
Publisher Lippincott Williams & Wilkins
Collection year 2012
Language eng
Formatted abstract
Background: Cardiovascular remodeling leading to heart failure is
common in the elderly. Testing effective pharmacological treatment of
human heart failure requires a suitable animal model that adequately
mimics the human disease state.
Methods: This study has characterized the structural, functional, and
electrical characteristics of the cardiovascular system throughout the
lifespan in male and female spontaneously hypertensive rats (SHRs),
a genetic model of chronic hypertension–induced cardiovascular remodeling,
and age- and gender-matched normotensive controls, to determinewhether
ageing SHRs mimic the changes seen in ageing humans.
Results: Both the ageing male and female SHRs developed progressive
hypertension, ventricular hypertrophy, left ventricular fibrosis, action
potential prolongation without impaired glucose tolerance. Male SHRs
from 15 months of age exhibited left ventricular wall thinning and
chamber dilation, together with systolic and diastolic dysfunction and
increased cardiac stiffness and increased erythrocyte superoxide production,
which were not present in the female SHRs.
Conclusion: Ageing male SHRs in contrast to the female SHRs, better
mimic the chronic heart failure in humans produced by chronic hypertension.
Ageing male SHRs could then be used to investigate proposed
therapeutic interventions for chronic congestive heart failure in humans.
Keyword Ageing
Heart failure
Spontaneously hypertensive rats
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

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Created: Fri, 05 Aug 2011, 12:16:56 EST by Susan Allen on behalf of Institute for Molecular Bioscience