A regenerative antioxidant protocol of vitamin E and α-lipoic acid ameliorates cardiovascular and metabolic changes in fructose-fed rats

Patel, Jatin, Matnor, Nur Azim, Iyer, Abishek and Brown, Lindsay (2011) A regenerative antioxidant protocol of vitamin E and α-lipoic acid ameliorates cardiovascular and metabolic changes in fructose-fed rats. Evidence Based Complementary and Alternative Medicine, 2011 : 120801-1-120801-8.


Author Patel, Jatin
Matnor, Nur Azim
Iyer, Abishek
Brown, Lindsay
Title A regenerative antioxidant protocol of vitamin E and α-lipoic acid ameliorates cardiovascular and metabolic changes in fructose-fed rats
Journal name Evidence Based Complementary and Alternative Medicine  (ERA 2012 Listed)    (ERA 2010 Rank A)   Check publisher's open access policy
Publication date 2011-03-09
Sub-type Article
DOI 10.1155/2011/120801
Volume number 2011
ISSN 1741-427X; 1741-4288
Start page 120801-1
End page 120801-8
Total pages 8
Place of publication New York, NY, United States
Publisher Hindawi Publishing Corporation
Collection year 2012
Language eng
Abstract Type 2 diabetes is a major cause of cardiovascular disease.We have determined whether the metabolic and cardiovascular changes induced by a diet high in fructose in young adult male Wistar rats could be prevented or reversed by chronic intervention with natural antioxidants. We administered a regenerative antioxidant protocol using two natural compounds: α-lipoic acid together with vitamin E (α-tocopherol alone or a tocotrienol-rich fraction), given as either a prevention or reversal protocol in the food. These rats developed glucose intolerance, hypertension, and increased collagen deposition in the heart together with an increased ventricular stiffness. Treatment with a fixed combination of vitamin E (either α-tocopherol or tocotrienol-rich fraction, 0.84 g/kg food) and α-lipoic acid (1.6 g/kg food) normalized glucose tolerance, blood pressure, cardiac collagen deposition, and ventricular stiffness in both prevention and reversal protocols in these fructose-fed rats. These results suggest that adequate antioxidant therapy can both prevent and reverse the metabolic and cardiovascular damage in type 2 diabetes.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

 
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Created: Fri, 05 Aug 2011, 12:07:29 EST by Susan Allen on behalf of Institute for Molecular Bioscience