Resveratrol improves cardiovascular function in DOCA-salt hypertensive rats

Chan, Vincent, Fenning, Andrew, Iyer, Abishek, Hoey, Andrew and Brown, Lindsay (2011) Resveratrol improves cardiovascular function in DOCA-salt hypertensive rats. Current Pharmaceutical Biotechnology, 12 3: 429-436. doi:10.2174/138920111794480552

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Author Chan, Vincent
Fenning, Andrew
Iyer, Abishek
Hoey, Andrew
Brown, Lindsay
Title Resveratrol improves cardiovascular function in DOCA-salt hypertensive rats
Journal name Current Pharmaceutical Biotechnology   Check publisher's open access policy
ISSN 1389-2010
1873-4316
Publication date 2011-03
Sub-type Article (original research)
DOI 10.2174/138920111794480552
Volume 12
Issue 3
Start page 429
End page 436
Total pages 8
Place of publication Bussum, Netherlands
Publisher Bentham Science Publishers
Collection year 2012
Language eng
Formatted abstract
The phytoalexin resveratrol (3,4',5-trihydroxy-trans-stilbene) may attenuate cardiovascular disease in man. This study has determined whether treatment with resveratrol (1 mg/kg/day orally) prevented cardiac fibrosis and the decreased cardiovascular function in the DOCA-salt hypertensive rat as a model of human hypertension. Uninephrectomised rats (UNX) administered DOCA (25mg every 4th day sc) and 1% NaCl in drinking water for 28 days developed cardiac and vascular remodelling. In these DOCA-salt rats, resveratrol decreased inflammatory cell infiltration, decreased cardiac fibrosis (left ventricular interstitial and perivascular collagen content) and improved cardiac and vascular function. Resveratrol attenuated other features of cardiovascular remodelling such as increases in systolic blood pressure, left ventricular wet weight, left ventricular wall thickness, diastolic stiffness constant, as well as decreased cardiac contractility and prolonged action potential duration characteristic of DOCA-salt rats. In summary, resveratrol, at a nutritionally relevant dose, prevents or attenuates the adverse changes in the cardiovascular system. We propose that the anti-inflammatory and anti-fibrotic effects of resveratrol are responsible, at least in part, for its amelioration of cardiovascular remodelling in DOCA-salt rats. These actions of resveratrol could play an important role in the protective effects on the human cardiovascular system reported for this constituent of red wine.
Keyword Resveratrol
Fibrosis
DOCA-salt
Hypertrophy
Collagen
Rats
Sirtuins
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Biomedical Sciences Publications
Institute for Molecular Bioscience - Publications
 
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Citation counts: TR Web of Science Citation Count  Cited 36 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 40 times in Scopus Article | Citations
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Created: Fri, 05 Aug 2011, 11:53:27 EST by Susan Allen on behalf of Institute for Molecular Bioscience