Control of mature protein function by allosteric disulfide bonds

Azimi, Iman, Wong, Jason W. H. and Hogg, Philip J. (2011) Control of mature protein function by allosteric disulfide bonds. Antioxidants and Redox Signaling, 14 1: 113-126. doi:10.1089/ars.2010.3620

Author Azimi, Iman
Wong, Jason W. H.
Hogg, Philip J.
Title Control of mature protein function by allosteric disulfide bonds
Journal name Antioxidants and Redox Signaling   Check publisher's open access policy
ISSN 1523-0864
Publication date 2011-01-01
Year available 2010
Sub-type Article (original research)
DOI 10.1089/ars.2010.3620
Volume 14
Issue 1
Start page 113
End page 126
Total pages 14
Place of publication New Rochelle, NY, United States
Publisher Mary Ann Liebert
Collection year 2012
Language eng
Abstract Protein disulfide bonds are the links between the sulfur atoms of two cysteine amino acids. All the known life forms appear to make this bond. Most disulfide bonds perform a structural role by stabilizing the tertiary and quaternary structures. Some perform a functional role and can be characterized as either catalytic or allosteric disulfides. Catalytic disulfides/dithiols transfer electrons between proteins, whereas the allosteric bonds control the function of the protein in which they reside when they undergo redox change. There are currently five clear examples of allosteric disulfide bonds and a number of potential allosteric disulfides at various stages of characterization. The features of these bonds and how they control the activity of the respective proteins are discussed. A common aspect of the allosteric disulfides identified to date is that they all link β-strands or β-loops.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status Non-UQ
Additional Notes Online Ahead of Print: October 28, 2010

Document type: Journal Article
Sub-type: Article (original research)
Collections: Non HERDC
School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 16 times in Thomson Reuters Web of Science Article | Citations
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Created: Mon, 01 Aug 2011, 12:45:15 EST by Mr Iman Azimi on behalf of School of Pharmacy