Plasma membrane calcium ATPases and cancer

Curry, Merril C., Roberts-Thomson, Sarah J. and Monteith, Gregory R. (2011) Plasma membrane calcium ATPases and cancer. BioFactors, 37 3: 132-138. doi:10.1002/biof.146

Author Curry, Merril C.
Roberts-Thomson, Sarah J.
Monteith, Gregory R.
Title Plasma membrane calcium ATPases and cancer
Journal name BioFactors   Check publisher's open access policy
ISSN 0951-6433
Publication date 2011
Sub-type Article (original research)
DOI 10.1002/biof.146
Volume 37
Issue 3
Start page 132
End page 138
Total pages 6
Place of publication Hoboken, NJ, U.S.A.
Publisher John Wiley & Sons
Collection year 2012
Language eng
Formatted abstract
The plasma membrane calcium ATPases (PMCAs) are vital regulators of basal Ca2+ and shape the nature of intracellular free Ca2+ transients after cellular stimuli and are thus regulators of a plethora of cellular processes. Studies spanning many years have identified that at least some cancers are associated with a remodeling of PMCA isoform expression. This alteration in Ca2+ efflux capacity may have a variety of consequences including reduced sensitivity to apoptosis and increases in the responsiveness of cancer cells to proliferative stimuli. In this review we provide an overview of studies focused on PMCAs in the context of cancer. We discuss how the remodeling of PMCA expression could provide a survival and/or growth advantage to cancer cells, as well as the potential of pharmacological agents that target specific PMCA isoforms to be novel therapies for the treatment of cancer.
Keyword Breast; Ca2+
P-type ATPases
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Pharmacy Publications
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Citation counts: TR Web of Science Citation Count  Cited 6 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 5 times in Scopus Article | Citations
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Created: Thu, 28 Jul 2011, 14:09:58 EST by Charna Kovacevic on behalf of School of Pharmacy