Phosphoinositides in cell architecture

Shewan, Annette, Eastburn, Dennis J. and Mostov, Keith (2011) Phosphoinositides in cell architecture. Cold Spring Harbor Perspectives in Biology, 3 8: a004796.1-a004796.17. doi:10.1101/cshperspect.a004796

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Author Shewan, Annette
Eastburn, Dennis J.
Mostov, Keith
Title Phosphoinositides in cell architecture
Journal name Cold Spring Harbor Perspectives in Biology   Check publisher's open access policy
ISSN 1943-0264
Publication date 2011-08
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1101/cshperspect.a004796
Open Access Status
Volume 3
Issue 8
Start page a004796.1
End page a004796.17
Total pages 17
Place of publication Woodbury, NY, United States
Publisher Cold Spring Harbor Laboratory Press
Collection year 2012
Language eng
Abstract Inositol phospholipids have been implicated in almost all aspects of cellular physiology including spatiotemporal regulation of cellular signaling, acquisition of cellular polarity, specification of membrane identity, cytoskeletal dynamics, and regulation of cellular adhesion, motility, and cytokinesis. In this review, we examine the critical role phosphoinositides play in these processes to execute the establishment and maintenance of cellular architecture. Epithelial tissues perform essential barrier and transport functions in almost all major organs. Key to their development and function is the establishment of epithelial cell polarity.We place a special emphasis on highlighting recent studies demonstrating phosphoinositide regulation of epithelial cell polarity and how individual cells use phosphoinositides to further organize into epithelial tissues.
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collections: Official 2012 Collection
School of Chemistry and Molecular Biosciences
 
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Citation counts: TR Web of Science Citation Count  Cited 54 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 53 times in Scopus Article | Citations
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Created: Tue, 26 Jul 2011, 14:53:09 EST by Dr Annette Shewan on behalf of School of Chemistry & Molecular Biosciences