Optical biosensors in drug discovery

Cooper, Matthew A. (2002) Optical biosensors in drug discovery. Nature Reviews Drug Discovery, 1 7: 515-528. doi:10.1038/nrd838


Author Cooper, Matthew A.
Title Optical biosensors in drug discovery
Journal name Nature Reviews Drug Discovery   Check publisher's open access policy
ISSN 1474-1776
1474-1784
Publication date 2002-07
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1038/nrd838
Volume 1
Issue 7
Start page 515
End page 528
Total pages 14
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Optical biosensors that exploit surface plasmon resonance, waveguides and resonant mirrors have been used widely over the past decade to analyse biomolecular interactions. These sensors allow the determination of the affinity and kinetics of a wide variety of molecular interactions in real time, without the need for a molecular tag or label. Advances in instrumentation and experimental design have led to the increasing application of optical biosensors in many areas of drug discovery, including target identification, ligand fishing, assay development, lead selection, early ADME and manufacturing quality control. This article reviews important advances in optical-biosensor instrumentation and applications, and also highlights some exciting developments, such as highly multiplexed optical-biosensor arrays.
Keyword Surface-plasmon resonance
Biomolecular interaction analysis
Protein-protein interactions
Self-assembled monolayers
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Institute for Molecular Bioscience - Publications
 
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