Differences between the sexes and the effects of surgery and anesthesia on the urinary-excretion rate of eicosinoids in the rat

Munger, K., Mitchell, M. and Baylis, C. (1989) Differences between the sexes and the effects of surgery and anesthesia on the urinary-excretion rate of eicosinoids in the rat. Prostaglandins, 37 3: 379-388. doi:10.1016/0090-6980(89)90008-7


Author Munger, K.
Mitchell, M.
Baylis, C.
Title Differences between the sexes and the effects of surgery and anesthesia on the urinary-excretion rate of eicosinoids in the rat
Journal name Prostaglandins   Check publisher's open access policy
ISSN 0090-6980
Publication date 1989-03
Sub-type Article (original research)
DOI 10.1016/0090-6980(89)90008-7
Volume 37
Issue 3
Start page 379
End page 388
Total pages 10
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Formatted abstract
Measurements were made of PGE2, PGF2 and TXB2 in the urine of male and female Munich-Wistar rats. Initial urine were collected in the awake state in metabolic cages and were followed by collections of ureteral urine during surgery and anesthesia both before and during cyclooxygenase inhibition with indomethacin. The excretion rate of all eicosinoids in the awake state was similar between the sexes. PGE2 excretion remained unaffected after anesthesia/surgery in both sexes indicating that providing plasma volume is maintained, the PGE2 system is not activated by the stress of anesthesia/surgery. Near complete inhibition of PGE2 was observed during indomethacin administration in both sexes. TXB2 excretion rates rose in both males and females with anesthesia/surgery and were slightly suppressed during indomethacin in males only. PGF2 excretion rose following surgery/anesthesia and was statistically significant in female rats. During indomethacin, TXB2 excretion was moderately reduced in male rats and unaffected in the female. Near complete inhibition of PGF2 was observed during indomethacin in both sexes. The urinary eicosinoid responses to indomethacin seen in these studies failed to provide an explanation for our earlier observations of a fall in renal vascular resistance in the female rat, studied under anesthesia and during indomethacin administration.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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