Effect of 48-Hour Infusion of the Synthetic Oxytocin Antagonist, [1-Beta Mercapto(Beta-(Ch2)5)1(Ome)Tyr2,Orn8]-Oxytocin, On Myometrial Activity of Pregnant Sheep At 139-140 Days of Gestation

Owiny, J.R., Mitchell, M. and Nathanielsz, P.W. (1992) Effect of 48-Hour Infusion of the Synthetic Oxytocin Antagonist, [1-Beta Mercapto(Beta-(Ch2)5)1(Ome)Tyr2,Orn8]-Oxytocin, On Myometrial Activity of Pregnant Sheep At 139-140 Days of Gestation. Biology of Reproduction, 47 3: 436-440. doi:10.1095/biolreprod47.3.436


Author Owiny, J.R.
Mitchell, M.
Nathanielsz, P.W.
Title Effect of 48-Hour Infusion of the Synthetic Oxytocin Antagonist, [1-Beta Mercapto(Beta-(Ch2)5)1(Ome)Tyr2,Orn8]-Oxytocin, On Myometrial Activity of Pregnant Sheep At 139-140 Days of Gestation
Formatted title
Effect of 48-hour infusion of the synthetic oxytocin antagonist, [1-beta-mercapto(beta-(CH2)5)1(OMe)Tyr2,Orn8]-oxytocin, on myometrial activity of pregnant sheep at 139-140 days of gestation.
Journal name Biology of Reproduction   Check publisher's open access policy
ISSN 0006-3363
1529-7268
Publication date 1992-09
Sub-type Article (original research)
DOI 10.1095/biolreprod47.3.436
Volume 47
Issue 3
Start page 436
End page 440
Total pages 5
Place of publication Madison, WI, United States
Publisher Society for the Study of Reproduction
Language eng
Formatted abstract
Currently there is considerable interest in the actions of oxytocin antagonists on the pregnant myometrium. Few studies have been conducted involving long-term infusions of oxytocin antagonists to late-pregnant experimental animals. We set out to determine whether continuous infusion of an oxytocin antagonist ([1-β-mercapto(β-(CH 2) 5) 1(OMe)Tyr 2,Orn 8]- oxytocin) would influence basal levels of myometrial activity of the contracture type and maternal prostaglandins in pregnant sheep. The antagonist was infused into a uterine vein at 80 μg · h -1 for 48 h starting at 139 days of gestational age. The antagonist significantly reduced total myometrial electromyogram activity and the frequency of contractures but did not change contracture duration. Antagonist infusion did not produce any significant alterations in maternal carotid or uterine vein 13,14- dihydro-15 keto prostaglandin F(2α) concentrations: Contractures probably represent an intrinsic instability of the resting membrane potential of uterine muscle and these results suggest that oxytocin may play a role in regulating their frequency in sheep during the last third of gestation.
Keyword Rhesus monkey
Uterine
Parturition
Plasma
Contractility
Sensitivity
Modulation
Uterus
Ewe
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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