Biophysical characteristics of oxytocin secretory granules isolated from ovine corpora lutea

Rice, G. E. (1988) Biophysical characteristics of oxytocin secretory granules isolated from ovine corpora lutea. Journal of Endocrinology, 116 2: 267-272. doi:10.1677/joe.0.1160267


Author Rice, G. E.
Title Biophysical characteristics of oxytocin secretory granules isolated from ovine corpora lutea
Journal name Journal of Endocrinology   Check publisher's open access policy
ISSN 0022-0795
1479-6805
Publication date 1988-02
Sub-type Article (original research)
DOI 10.1677/joe.0.1160267
Volume 116
Issue 2
Start page 267
End page 272
Total pages 6
Place of publication Bristol, United Kingdom
Publisher BioScientifica
Language eng
Abstract Luteal oxytocin-containing secretory granules have been isolated and characterized in terms of their physicochemical parameters. The isopynic sedimentation density (1·03 ±0·003 g/ml) and sedimentation coefficient (1670 S, 0·32 mol sucrose/l, 4 °C) of these granules have been estimated. Based upon these estimates, the average vesicle diameter (258 ± 17 nm) and vesicle weight (9·92 ±0·67 fg/vesicle) were calculated. The exchangeable water content (58·2%) of these granules was determined using density gradients prepared with deuterium oxide. Luteal oxytocin-containing granules displayed similar physicochemical characteristics to those reported for neurohypophysial peptide-containing granules, with the exception of particle size. Luteal granules were 1·3 times greater in diameter than neurohypophysial granules.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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