The effects of free radical scavengers on arachidonic acid metabolism by ovine placental microsomes

Rice, G. E. and Baker, M. S. (1991) The effects of free radical scavengers on arachidonic acid metabolism by ovine placental microsomes. General Pharmacology, 22 6: 1109-1113. doi:10.1016/0306-3623(91)90586-U


Author Rice, G. E.
Baker, M. S.
Title The effects of free radical scavengers on arachidonic acid metabolism by ovine placental microsomes
Journal name General Pharmacology   Check publisher's open access policy
ISSN 0306-3623
1879-0011
Publication date 1991
Sub-type Article (original research)
DOI 10.1016/0306-3623(91)90586-U
Volume 22
Issue 6
Start page 1109
End page 1113
Total pages 5
Place of publication Philadelphia, PA, United States
Publisher Elsevier
Language eng
Formatted abstract
1. The effect of free radical (superoxide and hydroxyl) and hydrogen peroxide scavengers on the formation of prostaglandin E2 by ovine placental microsomes was investigated.

2. Of the free radical scavengers tested only Mn Desferal, a low molecular weight (712 Da) superoxide scavenger, at concentrations of 0.5-5 mmol/l significantly (P < 0.001) stimulated PGE2 formation by ovine placental microsomes.

3. This observation is consistent with the involvement of superoxide radicals in the inactivation of prostaglandin G/H synthase (PGHS).

4. The results obtained further suggest that if superoxide radicals are important regulators of PGHS activity in the ovine placenta, they are not accessible to large molecular weight free radical scavengers.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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