Leukemia inhibitory factor: Association with intraamniotic infection

Waring, P. M., Romero, R., Laham, N., Gomez, R. and Rice, G. E. (1994) Leukemia inhibitory factor: Association with intraamniotic infection. American Journal of Obstetrics and Gynecology, 171 5: 1335-1341.

Author Waring, P. M.
Romero, R.
Laham, N.
Gomez, R.
Rice, G. E.
Title Leukemia inhibitory factor: Association with intraamniotic infection
Journal name American Journal of Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0002-9378
1097-6868
Publication date 1994-11
Sub-type Article (original research)
Volume 171
Issue 5
Start page 1335
End page 1341
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Mosby
Language eng
Formatted abstract
Objective: Our purpose was to investigate whether leukemia inhibitory factor is associated with intraamniotic infection.
Study design: A comparative clinical study of amniotic fluid leukemia inhibitory factor concentrations was performed.
Results: Leukemia inhibitory factor was undetectable (<1 ng/ml) by radioreceptor assay during normal pregnancy at midtrimester and at term. Among women in labor those with intraamniotic infection had higher leukemia factor concentrations than those without infection before term (p < 0.001) and at term (p < 0.005). The leukemia inhibitory factor concentrations correlated with the amniotic fluid white blood cell counts (r = 0.47) (p < 0.001). In cultured human gestational tissue explants, leukemia inhibitory factor release was significantly enhanced by endotoxin, interleukin-1α, and tumor necrosis factor-α however, leukemia inhibitory factor did not enhance the release of prostaglandin E2 by these tissues.
Conclusions: Amniotic fluid leukemia inhibitory factor concentrations were elevated during intraamniotic infection and gestational tissues released leukemia inhibitory factor in response to bacterial products and inflammatory mediators.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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