Eosinophil cationic protein and eosinophil protein X: Human amniotic fluid concentrations and gestational tissue content at term

Rice, G. E., Reimert, C. M. and Bendtzen, K. (1998) Eosinophil cationic protein and eosinophil protein X: Human amniotic fluid concentrations and gestational tissue content at term. Placenta, 19 2-3: 181-185. doi:10.1016/S0143-4004(98)90007-8


Author Rice, G. E.
Reimert, C. M.
Bendtzen, K.
Title Eosinophil cationic protein and eosinophil protein X: Human amniotic fluid concentrations and gestational tissue content at term
Journal name Placenta   Check publisher's open access policy
ISSN 0143-4004
1532-3102
Publication date 1998-03
Sub-type Article (original research)
DOI 10.1016/S0143-4004(98)90007-8
Volume 19
Issue 2-3
Start page 181
End page 185
Total pages 5
Place of publication Oxford, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
The aim of this study was to determine the presence and concentration of immunoreactive eosinophilcationicprotein (ECP) and eosinophilprotein X (EPX) in humanamnioticfluid at term and assess labour-associated changes in their mean concentrations. In addition, ECP and EPX content in term amnion, choriodecidua and placenta obtained before and after labour and delivery was established. Immunoreactive ECP and EPX were identified in all samples of amnioticfluid (n=47) and gestationaltissue (n=60) assayed. EPX was quantitatively more abundant than ECP in both amnioticfluid and gestationaltissues. In amnioticfluid, ECP and EPX concentrations increased 8-fold (P<0.02) and 1.5-fold (P<0.02), respectively, with labour onset. In gestationaltissues, a labour-associated change in tissuecontent was only identified for ECP in choriodecidua, which increased 1.9-fold with labour and delivery (P<0.01). The labour-associated increase in amnioticfluidconcentrations of ECP and EPX demonstrated in this study is consistent with the well-characterized role of these proteins in inflammatory reactions. It remains to be established whether the observed increase in ECP and EPX amnioticfluidconcentrations is an epiphenomenon of labour onset or is involved causally in this process.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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