Mutation analysis of CDP, TP53, and KRAS in uterine leiomyomas

Patrikis, Maria I., Bryan, Emma J., Thomas, Nicola A., Rice, Gregory E., Quinn, Michael A., Baker, Mark S. and Campbell, Ian G. (2003) Mutation analysis of CDP, TP53, and KRAS in uterine leiomyomas. Molecular Carcinogenesis, 37 2: 61-64. doi:10.1002/mc.10127

Author Patrikis, Maria I.
Bryan, Emma J.
Thomas, Nicola A.
Rice, Gregory E.
Quinn, Michael A.
Baker, Mark S.
Campbell, Ian G.
Title Mutation analysis of CDP, TP53, and KRAS in uterine leiomyomas
Journal name Molecular Carcinogenesis   Check publisher's open access policy
ISSN 0899-1987
Publication date 2003-06
Sub-type Article (original research)
DOI 10.1002/mc.10127
Volume 37
Issue 2
Start page 61
End page 64
Total pages 4
Place of publication Hoboken, NJ, United States
Publisher John Wiley & Sons
Language eng
Formatted abstract
Leiomyomas are the most common gynecologic tumors in women, but very little is known about their molecular pathology. We used single-stranded conformational polymorphism/heteroduplex analysis to analyze 42 unselected uterine leiomyomas for somatic mutations in all coding exons of the gene encoding CCAAT displacement protein (CDP), as well as exons 5-8 of TP53 and codons 1-36 and 38-80 of KRAS. No somatic mutations were identified in either TP53 or KRAS, indicating that disregulation of these genes is not required for leiomyomas development. Aberrant band shifts were identified in CDP, but these were all germline nonpathogenic variants that have been reported previously. There is good functional and genetic evidence indicating that CDP is a leiomyoma suppressor, but our data suggested that somatic mutations in this gene were rare in unselected uterine leiomyomas. It is possible that CDP belongs to a class of tumor suppressor in which loss of only one copy of the gene, either by genetic or epigenetic mechanisms, is sufficient to allow tumor growth.
Keyword Uterine leiomyoma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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