Phospholipase A(2) isozymes in pregnancy and parturition

Lappas, M. and Rice, G. E. (2004) Phospholipase A(2) isozymes in pregnancy and parturition. Prostaglandins Leukotrienes and Essential Fatty Acids, 70 2: 87-100. doi:10.1016/j.plefa.2003.04.001


Author Lappas, M.
Rice, G. E.
Title Phospholipase A(2) isozymes in pregnancy and parturition
Journal name Prostaglandins Leukotrienes and Essential Fatty Acids   Check publisher's open access policy
ISSN 0952-3278
1532-2823
Publication date 2004-02
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1016/j.plefa.2003.04.001
Volume 70
Issue 2
Start page 87
End page 100
Total pages 14
Place of publication Kidlington, United Kingdom
Publisher Churchill Livingstone
Language eng
Formatted abstract
Mammalian cells contain several structurally different phospholipase (PLA2) enzymes that exhibit distinct localisation, function and mechanisms of regulation. PLA2 isozymes have been postulated to play significant roles in the parturition process. Both secretory and cytosolic PLA2 isozymes have been identified in human gestational tissues, and there is differential expression of these PLA2 isozymes in human fetal membranes and placenta obtained at preterm and term. The aims of this commentary are: (1) to review recent data concerning the expression, role and regulation of PLA2 isozymes in human gestational tissues; and (2) to present novel data demonstrating the regulation of PLA2 isozymes in human gestational tissues by nuclear factor-kappa B (NF-κB) and peroxisome proliferator-activated receptor (PPAR)-g.
Keyword Secretory pla2
Cytosolic PLA2
Pregnancy
Preterm labour
Nf-kappa B
Ppar
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: UQ Centre for Clinical Research Publications
 
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