μ- and κ-opiate receptor agonists reduce plasma neurohypophysial hormone concentrations in water-deprived and normally hydrated rats

Evans, R. G., Olley, J. E., Rice, G. E. and Abrahams, J. M. (1989) μ- and κ-opiate receptor agonists reduce plasma neurohypophysial hormone concentrations in water-deprived and normally hydrated rats. Clinical and Experimental Pharmacology and Physiology, 16 3: 191-197. doi:10.1111/j.1440-1681.1989.tb01544.x


Author Evans, R. G.
Olley, J. E.
Rice, G. E.
Abrahams, J. M.
Title μ- and κ-opiate receptor agonists reduce plasma neurohypophysial hormone concentrations in water-deprived and normally hydrated rats
Journal name Clinical and Experimental Pharmacology and Physiology   Check publisher's open access policy
ISSN 0305-1870
1440-1681
Publication date 1989-03-01
Sub-type Article (original research)
DOI 10.1111/j.1440-1681.1989.tb01544.x
Volume 16
Issue 3
Start page 191
End page 197
Total pages 7
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell
Language eng
Formatted abstract
1. The effects of μ- and κ-opiate receptor agonists on plasma concentrations of immunoreactive (ir) oxytocin (OXY) and arginine vasopressin (AVP) in normally hydrated and water-deprived rats were studied.

2. Water-deprivation for 36 h elevated both plasma ir-OXY and ir-AVP concentrations of Long-Evans rats. These elevated levels were lowered in a dose-dependent manner after subcutaneous administration of bremazocine (3-10 μg/kg), M320 (10-100 μg/kg) or morphine (0.1-10 mg/kg). Comparable reductions of plasma concentrations of ir-AVP and ir-OXY were observed.

3. Plasma concentrations of ir-OXY and ir-AVP of normally hydrated Long-Evans rats were lower after subcutaneous administration of bremazocine (10 μg/kg), M320 (10 μg/kg) and morphine (1.0 mg/kg).

4. These data suggest that both μ- and κ-opiate receptor agonists inhibit both OXY and AVP release from the neurohypophysis of rats.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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