Gestational tissue phospholipase A2 messenger RNA content and the onset of spontaneous labour in the human

Aitken, M. A., Rice, G. E. and Brennecke, S. P. (1990) Gestational tissue phospholipase A2 messenger RNA content and the onset of spontaneous labour in the human. Reproduction Fertility and Development, 2 5: 575-580. doi:10.1071/RD9900575


Author Aitken, M. A.
Rice, G. E.
Brennecke, S. P.
Title Gestational tissue phospholipase A2 messenger RNA content and the onset of spontaneous labour in the human
Journal name Reproduction Fertility and Development   Check publisher's open access policy
ISSN 1031-3613
1448-5990
Publication date 1990-01-01
Sub-type Article (original research)
DOI 10.1071/RD9900575
Volume 2
Issue 5
Start page 575
End page 580
Total pages 6
Place of publication Collingwood, Vic., Australia
Publisher CSIRO Publishing
Language eng
Abstract Considerable evidence supports a central role for prostaglandins in the genesis of uterine activity and cervical dilatation at the time of human labour. The first step in prostaglandin synthesis is the liberation of arachidonic acid from glycerophospholipids by phospholipase A2. In this study, we examined the periparturitional gene expression of PLA2 in human placentae and fetal membranes, using a cDNA clone for non-pancreatic PLA2. PLA2 gene expression was found to be significantly increased (P less than 0.05) in placentae obtained after spontaneous-onset labour and normal vaginal delivery as compared with placentae from elective Caesarean section. In both of these groups, PLA2 expression in amnion and chorion was significantly less than that in placenta. The results of this study suggest that placental PLA2 gene expression increases in association with spontaneous-onset of labour in the human. This conclusion is consistent with the finding of increased levels of prostaglandins in gestational tissues, amniotic fluid and blood plasma at the time of labour.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 35 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 29 times in Scopus Article | Citations
Google Scholar Search Google Scholar
Created: Sat, 16 Jul 2011, 00:46:27 EST by System User on behalf of UQ Centre for Clinical Research