Tumour necrosis factor α during human pregnancy and labour: Maternal plasma and amniotic fluid concentrations and release from intrauterine tissues

Laham, N., Brennecke, S. P., Bendtzen, K. and Rice, G. E. (1994) Tumour necrosis factor α during human pregnancy and labour: Maternal plasma and amniotic fluid concentrations and release from intrauterine tissues. European Journal of Endocrinology, 131 6: 607-614.

Author Laham, N.
Brennecke, S. P.
Bendtzen, K.
Rice, G. E.
Title Tumour necrosis factor α during human pregnancy and labour: Maternal plasma and amniotic fluid concentrations and release from intrauterine tissues
Formatted title
Tumour necrosis factor α during human pregnancy and labour: Maternal plasma and amniotic fluid concentrations and release from intrauterine tissues
Journal name European Journal of Endocrinology   Check publisher's open access policy
ISSN 0804-4643
1479-683X
Publication date 1994-12
Sub-type Article (original research)
Volume 131
Issue 6
Start page 607
End page 614
Total pages 8
Place of publication Bristol, United Kingdom
Publisher BioScientifica
Language eng
Formatted abstract
The aims of this study were: to quantify immunoreactive tumour necrosis factor α (TNF-α) concentrations in maternal plasma and amniotic fluid obtained from women during pregnancy and labour, both at term and preterm; and to establish the effects of bacterial endotoxin and cytokines on the in vitro release of TNF-α from intrauterine tissues. Maternal plasma TNF-α concentrations did not change during pregnancy (457.2 ± 102.9 ng/l, mean ± SEM, N=52) or at the time of labour (543.5 ± 138.6 ng/l, N = 43). In contrast, amniotic fluid TNF-α concentrations increased significantly (p < 0.05) during pregnancy (early pregnancy, EP, 93.0 ± 24.8 ng/l, N = 7; preterm not-in-labour, PNIL, 186.8 ± 42.9 ng/L N=16; term not-in-labour, TNIL, 499.7 ± 150.9ng/l, N=13) and in association with preterm labour (preterm in-labour, PIL, 958.7 ± 575.6ng/l, N = 5 vs PNIL. 186.8 ± 42.9 ng/l, N = 16). Choriodecidual and placental explants (N = 3) maintained in in vitro culture released TNF-α Furthermore, the release of TNF-α was increased significantly (p < 0.05) by bacterial endotoxin (lipopolysaccharide, 10ng/l-10mg/l) but was not affected by the following cytokines at the indicated doses: interleukin-1α (0.28 nmol/l), interleukin-6 (12.5 nmol/l), granulocyte colony-stimulating factor (2.5 nmol/l). granulocyte-macrophage colonystimulating factor (35mnol/1) macrophage colony-stimulating factor (1.2nmol/l), leukaemia inhibitory factor (0.45 nmol/l) and transforming growth factor-β (0.4nmol/l). The data obtained in this study are consistent with a role for TNF-α in bot h preterm labour and normal labour at term.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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