Differential release of interleukin-6 from human gestational tissues in association with labour and in vitro endotoxin treatment

Laham, N., Brennecke, S. P., Bendtzen, K. and Rice, G. E. (1996) Differential release of interleukin-6 from human gestational tissues in association with labour and in vitro endotoxin treatment. Journal of Endocrinology, 149 3: 431-439. doi:10.1677/joe.0.1490431


Author Laham, N.
Brennecke, S. P.
Bendtzen, K.
Rice, G. E.
Title Differential release of interleukin-6 from human gestational tissues in association with labour and in vitro endotoxin treatment
Formatted title
Differential release of interleukin-6 from human gestational tissues in association with labour and in vitro endotoxin treatment
Journal name Journal of Endocrinology   Check publisher's open access policy
ISSN 0022-0795
1479-6805
Publication date 1996-06
Sub-type Article (original research)
DOI 10.1677/joe.0.1490431
Volume 149
Issue 3
Start page 431
End page 439
Total pages 9
Place of publication Oxford University Press
Publisher Oxford, United Kingdom
Language eng
Formatted abstract
In this study, we quantified interleukin-6 (IL-6) concentrations in amniotic fluid at term and preterm labour, and determined the gestational tissue source of IL-6. In addition, aspects of the regulatory mechanisms involved in IL-6 release at the time of term labour and in response to bacterial endotoxin, lipopolysaccharide (LPS), have been established. IL-6 concentrations were 2-fold higher in amniotic fluid collected at term compared with preterm gestation, with an additional 2-fold increase in association with term labour. IL-6 was released from all choriodecidual and placental explants but was detected in only 33% of amniotic explant cultures of tissues obtained before labour onset. In contrast, IL-6 was detected in all amniotic, choriodecidual and placental cultures of tissues obtained after term labour onset and delivery, and the mean IL-6 release was significantly higher than that measured in explant cultures of both amniotic (80-fold increase, P<0·0001) and choriodecidual (3-fold increase, P<0·02) but not placental explants taken at the time of elective Caesarean section at term before labour onset. LPS significantly (P<0·05) increased the release of IL-6 from human choriodecidual and placental explants but not amniotic explants, in a time- and dose-dependent manner. IL-6 is a physiological constituent of amniotic fluid and its production by gestational tissues is differentially regulated by LPS and spontaneous labour onset and delivery.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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