Labour-associated increase in interleukin-1 alpha release in vitro by human gestational tissues

Laham, N., Brennecke, S. P., Bendtzen, K. and Rice, G. E. (1996) Labour-associated increase in interleukin-1 alpha release in vitro by human gestational tissues. Journal of Endocrinology, 150 3: 515-522. doi:10.1677/joe.0.1500515


Author Laham, N.
Brennecke, S. P.
Bendtzen, K.
Rice, G. E.
Title Labour-associated increase in interleukin-1 alpha release in vitro by human gestational tissues
Journal name Journal of Endocrinology   Check publisher's open access policy
ISSN 0022-0795
1479-6805
Publication date 1996-09-01
Sub-type Article (original research)
DOI 10.1677/joe.0.1500515
Volume 150
Issue 3
Start page 515
End page 522
Total pages 8
Place of publication Bristol, United Kingdom
Publisher BioScientifica
Language eng
Formatted abstract
The aims of this study were to investigate the concentration and release of interleukin-1α (IL-1α) at the time of human term labour, and to study the regulation of IL-1α release from human gestational tissue explants by bacterial endotoxin. Immunoreactive IL-1α concentrations in maternal plasma, amniotic fluid and conditioned media from human amniotic, choriodecidual and placental explants were quantified before and after spontaneous term labour-onset and delivery. Furthermore, the effects of a bacterial endotoxin, lipopolysaccharide (LPS), on the release of IL-1α from human gestational tissue explants over a time course of 24 h (n = 3) and LPS concentrations ranging from 10-107 pg/ml (n = 3) were investigated. IL-1α concentrations in maternal plasma and amniotic fluid did not change significantly with spontaneous term labour-onset. In contrast, IL-1α was released in detectable amounts from human amniotic and choriodecidual explants only in association with term labour-onset and delivery. Similarly, placental release of IL-1α was increased significantly in explant cultures in association with term labour-onset and delivery. LPS increased IL-1α release significantly only from human placental explants from both term not-in-labour and term after-labour tissues. The data demonstrate differential regulation of IL-1α release from human gestational tissues in association with labour and LPS treatment and the observations support the hypothesis that the labour-associated increase in IL-1α release from the fetal membranes is independent of exposure to bacterial endotoxin.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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