Type II phospholipase A(2) in preterm human gestational tissues

Lappas, M., Permezel, M., Georgiou, H. M. and Rice, G. E. (2001) Type II phospholipase A(2) in preterm human gestational tissues. Placenta, 22 1: 64-69. doi:10.1053/plac.2000.0586

Author Lappas, M.
Permezel, M.
Georgiou, H. M.
Rice, G. E.
Title Type II phospholipase A(2) in preterm human gestational tissues
Journal name Placenta   Check publisher's open access policy
ISSN 0143-4004
Publication date 2001-01
Sub-type Article (original research)
DOI 10.1053/plac.2000.0586
Volume 22
Issue 1
Start page 64
End page 69
Total pages 6
Place of publication Oxford, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
Maternal genital tract infections and the associated inflammatory response may contribute to the onset of many cases of preterm labour. Type II phospholipase A2 (PLA2) hydrolyses glycerophospholipids, releasing free fatty acid for conversion into potent biological mediators, such as prostaglandins, which play a significant role in both the onset and progression of human labour and the activation of inflammatory reactions. The aim of this study was to quantify immunoreactive (ir) Type II PLA2 in placenta, amnion and choriodecidua collected from women delivering prematurely or due to histological chorioamnionitis, and to compare levels to those at term. Tissues were assayed for ir Type II PLA2 by ELISA and expressed as ng/mg tissue protein. Ir Type II PLA2 tissue content was significantly higher in preterm (n=26) amnion and choriodecidua, but not in the placenta when compared to tissues obtained at term (n=42). When the data were stratified with respect to labour status, ir Type II PLA2 content was significantly higher in the preterm not-in-labour group (NIL, n=17) than the preterm in labour group (IL, n=9) in the amnion. When the NIL group was analysed with respect to membrane rupture, women who had spontaneously ruptured membranes (n=6) expressed significantly greater ir Type II PLA2 than those that had intact membranes (n=11) in both the amnion and choriodecidua but not in the placenta. No significant difference was observed between the preterm IL group (n=9) and the group with histological chorioamnionitis (n=14). The data obtained in this study support a role for Type II PLA2 in association with spontaneous rupture of membranes.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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