Elevated interleukin-8 concentrations in cervical secretions are associated with preterm labour

Dowd, J., Laham, N., Rice, G., Brennecke, S. and Permezel, M. (2001) Elevated interleukin-8 concentrations in cervical secretions are associated with preterm labour. Gynecologic and Obstetric Investigation, 51 3: 165-168. doi:10.1159/000052917


Author Dowd, J.
Laham, N.
Rice, G.
Brennecke, S.
Permezel, M.
Title Elevated interleukin-8 concentrations in cervical secretions are associated with preterm labour
Journal name Gynecologic and Obstetric Investigation   Check publisher's open access policy
ISSN 0378-7346
1423-002X
Publication date 2001
Sub-type Article (original research)
DOI 10.1159/000052917
Volume 51
Issue 3
Start page 165
End page 168
Total pages 4
Place of publication Basel, Switzerland
Publisher Karger
Language eng
Abstract The aim of this study was to assess the potential clinical utility of interleukin-8 (IL-8) present in cervical secretions as a marker of preterm labour and delivery. Samples of cervical mucus from 91 pregnant women were assessed for the presence and concentration of IL-8. Two samples were collected (at 18 ± 2 and 28 ± 2.5 weeks of gestation) and correlated with cervicovaginal microbiology and cervical length, as measured by transvaginal ultrasound. The IL-8 concentration at 28/40 was significantly higher in women who went on to deliver preterm (p < 0.01), and there was a greater than five-fold increase from 18 to 28 weeks in 6/7 of these women.
Keyword Interleukin-8
Preterm labour
Cervical secretions
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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