Altered placental oxidative stress status in gestational diabetes mellitus

Coughlan, M. T., Vervaart, P. P., Permezel, M., Georgiou, H. M. and Rice, G. E. (2004) Altered placental oxidative stress status in gestational diabetes mellitus. Placenta, 25 1: 78-84. doi:10.1016/S0143-4004(03)00183-8

Author Coughlan, M. T.
Vervaart, P. P.
Permezel, M.
Georgiou, H. M.
Rice, G. E.
Title Altered placental oxidative stress status in gestational diabetes mellitus
Journal name Placenta   Check publisher's open access policy
ISSN 0143-4004
Publication date 2004-01
Sub-type Article (original research)
DOI 10.1016/S0143-4004(03)00183-8
Volume 25
Issue 1
Start page 78
End page 84
Total pages 7
Place of publication Oxford, United Kingdom
Publisher Elsevier
Language eng
Formatted abstract
Oxidative stress has been clearly linked to type 2 diabetes mellitus, however, limited data are available on the involvement of oxidative stress in gestational diabetes mellitus (GDM), a disease of similar pathophysiology. The aim of this study was to investigate the status of placental oxidative stress in healthy pregnant women and women with GDM. The hypothesis to be tested was that tissue markers of oxidative stress are significantly increased in GDM compared to normal placental tissues. Markers of oxidative stress measured were the release of 8-isoprostane (8-epi-prostaglandin F2α) from human term placental explants (n=11), the activity of the antioxidant enzymes superoxide dismutase and glutathione peroxidase (n=10), and protein carbonyl content (n=12). Placental release of 8-isoprostane was 2-fold greater from women with GDM (P<0.001) compared to healthy pregnant women. Superoxide dismutase activity and protein carbonyl content were elevated in placentae obtained from women with GDM (P<0.04 and P<0.004 respectively), whilst there was no significant difference in the activity of glutathione peroxidase. These data demonstrate the presence of oxidative stress in the placenta from women with GDM, in addition to the induction of a key antioxidant, collectively indicating a state of existing oxidative stress in this condition.
Keyword Increased lipid-peroxidation
Protein carbonylation
Platelet activation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
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