Are alterations in plasma protease concentrations during labor associated with poor obstetric outcomes?

Knight, Rachel L., Rice, Gregory E. and Permezel, Michael (2005) Are alterations in plasma protease concentrations during labor associated with poor obstetric outcomes?. American Journal of Obstetrics and Gynecology, 193 1: 283-288. doi:10.1016/j.ajog.2004.10.631


Author Knight, Rachel L.
Rice, Gregory E.
Permezel, Michael
Title Are alterations in plasma protease concentrations during labor associated with poor obstetric outcomes?
Journal name American Journal of Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0002-9378
1097-6868
1085-8709
Publication date 2005-07
Sub-type Article (original research)
DOI 10.1016/j.ajog.2004.10.631
Volume 193
Issue 1
Start page 283
End page 288
Total pages 6
Place of publication United States
Publisher Mosby
Language eng
Formatted abstract
Objective: The purpose of this study was to assess the association between abnormal connectivetissue remodeling during labor as reflected by plasma concentrations of extracellular matrix remodeling proteolytic enzymes and adverse obstetric outcomes.
Study design: A prospective observational study of 176 nulliparous women who attended theantenatal clinics at the Mercy Hospital for Women (Melbourne, Australia) from 1999 to 2000.
Results: Patients with a prolonged second stage (>120 minutes) had a significantly increased plasma concentration of matrix metalloproteinase 9 after delivery compared with control subjects (P > .001); patients in labor who underwent an emergency caesarean delivery had a significantly lower concentration (P > .001). Patients with a prolonged duration of labor (>11 hours) had a significantly lower urokinase plasminogen activator plasma concentration compared with control subjects (P > .01).
Conclusion: Altered plasma concentrations of extracellular matrix remodeling proteolytic enzymes, matrix metalloproteinase 9, and urokinase plasminogen activator were found to be associated with abnormal labor and delivery outcomes. This finding may provide a useful predictor of abnormal obstetric outcomes.
Keyword Plasma concentration
Remodeling
IV collagenase matrix-metalloproteinase-9
Plasminogen-activator
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: UQ Centre for Clinical Research Publications
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