Interleukin-1 receptor antagonist in human cervicovaginal fluid in term pregnancy and labor

Heng, Yujing J., Di Quinzio, Megan K. W., Permezel, Michael, Rice, Gregory E. and Georgiou, Harry M. (2008) Interleukin-1 receptor antagonist in human cervicovaginal fluid in term pregnancy and labor. American Journal of Obstetrics and Gynecology, 199 6: 656.e1-656.e7. doi:10.1016/j.ajog.2008.06.011


Author Heng, Yujing J.
Di Quinzio, Megan K. W.
Permezel, Michael
Rice, Gregory E.
Georgiou, Harry M.
Title Interleukin-1 receptor antagonist in human cervicovaginal fluid in term pregnancy and labor
Journal name American Journal of Obstetrics and Gynecology   Check publisher's open access policy
ISSN 0002-9378
1097-6868
Publication date 2008-12
Sub-type Article (original research)
DOI 10.1016/j.ajog.2008.06.011
Volume 199
Issue 6
Start page 656.e1
End page 656.e7
Total pages 7
Place of publication Philadelphia, PA, United States
Publisher Mosby
Language eng
Formatted abstract
Objective
The objective of the study was to investigate temporal changes in interleukin-1 receptor antagonist (IL-1ra) in human cervicovaginal fluid (CVF) in term pregnancy and labor.
Study Design
CVF was collected weekly from 155 multiparous women from 36 weeks' gestation until labor. High vaginal swabs were collected for microbiology assessment.
Results
IL-1ra was decreased in spontaneous term labor, compared with 15-21 and 22-28 days from labor, and was significantly lower at 0-7 days, compared with 15-21 days before labor (P < .05, 2-way ANOVA). After subdividing the women, IL-1ra concentrations were 6-fold lower in women who had prelabor rupture of membranes at term than women who had spontaneous labor with intact membranes at 8-14 and 15-21 days before labor (P < .05, Student t test). IL-1ra concentrations were not affected by the microbial status of the vagina.
Conclusions
The changes in IL-1ra concentrations observed in the CVF may be linked to the remodeling of fetal membranes leading to rupture.
Keyword Biomarker
Cervicovaginal fluid
Interleukin-1 receptor antagonist
Pregnancy
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: UQ Centre for Clinical Research Publications
 
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