Resveratrol - pills to replace a healthy diet?

Chachay, Veronique S., Kirkpatrick, Carl M. J., Hickman, Ingrid J., Ferguson, Maree, Prins, Johannes B. and Martin, Jennifer H. (2011) Resveratrol - pills to replace a healthy diet?. British Journal of Clinical Pharmacology, 72 1: 27-38. doi:10.1111/j.1365-2125.2011.03966.x

Author Chachay, Veronique S.
Kirkpatrick, Carl M. J.
Hickman, Ingrid J.
Ferguson, Maree
Prins, Johannes B.
Martin, Jennifer H.
Title Resveratrol - pills to replace a healthy diet?
Journal name British Journal of Clinical Pharmacology   Check publisher's open access policy
ISSN 0306-5251
Publication date 2011-07
Sub-type Article (original research)
DOI 10.1111/j.1365-2125.2011.03966.x
Volume 72
Issue 1
Start page 27
End page 38
Total pages 13
Place of publication Oxford, United Kingdom
Publisher Wiley-Blackwell Publishing
Collection year 2012
Language eng
Formatted abstract
Nutrapharmacology, or the use of bioactive food compounds at pharmacological doses is emerging as a therapeutic approach to
target the complex metabolic dysregulations in ageing and obesity-related chronic disease. Resveratrol, a polyphenol found in the skin
of grapes, and other edible plants and related food products, has received extensive attention through the link with the French
paradox, and later with its chemopreventive activity demonstrated in vitro and in animal cancer models. A plethora of laboratory
investigations has provided evidence for the multi-faceted properties of resveratrol and suggests that resveratrol may target ageing
and obesity-related chronic disease by regulating inflammation and oxidative stress. A number of obstacles stand in the path to clinical
usage however, not least the lack of clinical evidence to date, and the myriad of doses and formulations available. Further, data on the
effects of resveratrol consumption in a capsule vs. food form is conflicting, and there are uncertain effects of long term dosing. The
review will summarize the human pharmacokinetic and pharmacodynamic published data, and the topics for research if resveratrol is
to become a multi-target therapeutic agent addressing chronic disease.
Keyword Bioactive food compounds
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
School of Pharmacy Publications
UQ Diamantina Institute Publications
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Created: Fri, 08 Jul 2011, 10:46:47 EST by Dr Jennifer Martin on behalf of Mater Clinical School