Human pigmentation genetics: The difference is only skin deep

Sturm, Richard A., Box, Neil F. and Ramsay, Michele (1998) Human pigmentation genetics: The difference is only skin deep. Bioessays, 20 9: 712-721. doi:10.1002/(SICI)1521-1878(199809)20:9<712::AID-BIES4>3.0.CO;2-I


Author Sturm, Richard A.
Box, Neil F.
Ramsay, Michele
Title Human pigmentation genetics: The difference is only skin deep
Journal name Bioessays   Check publisher's open access policy
ISSN 0265-9247
1521-1878
Publication date 1998-09
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/(SICI)1521-1878(199809)20:9<712::AID-BIES4>3.0.CO;2-I
Volume 20
Issue 9
Start page 712
End page 721
Total pages 10
Place of publication Bognor Regis, West Sussex, United Kingdom
Publisher John Wiley & Sons
Language eng
Abstract There is no doubt that visual impressions of body form and color are important in the interactions within and between human communities. Remarkably, it is the levels of just one chemically inert and stable visual pigment known as melanin that is responsible for producing all shades of humankind. Major human genes involved in its formation have been identified largely using a comparative genomics approach and through the molecular analysis of the pigmentary process that occurs within the melanocyte. Three classes of genes have been examined for their contribution to normal human color variation through the production of hypopigmented phenotypes or by genetic association with skin type and hair color. The MSH cell surface receptor and the melanosomal P-protein are the two most obvious candidate genes influencing variation in pigmentation phenotype, and may do so by regulating the levels and activities of the melanogenic enzymes tyrosinase, TRP-1 and TRP-2.
Keyword Melanin
Human genes
Comparative genomics
Melanocyte
Pigmentation phenotype
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: Institute for Molecular Bioscience - Publications
 
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