Human pigmentation genes and their response to solar UV radiation

Sturm, Richard A. (1998). Human pigmentation genes and their response to solar UV radiation. In: 1st Mount Buller International Conference on Environmental Radiation, Mount Buller, VIC, Australia, (69-76). December 1996. doi:10.1016/S0027-5107(98)00176-6


Author Sturm, Richard A.
Title of paper Human pigmentation genes and their response to solar UV radiation
Conference name 1st Mount Buller International Conference on Environmental Radiation
Conference location Mount Buller, VIC, Australia
Conference dates December 1996
Journal name Mutation Research-Fundamental and Molecular Mechanisms of Mutagenesis   Check publisher's open access policy
Place of Publication Amsterdam, Netherlands
Publisher Elsevier
Publication Year 1998
Sub-type Fully published paper
DOI 10.1016/S0027-5107(98)00176-6
ISSN 0027-5107
1386-1964
Volume 422
Issue 1
Start page 69
End page 76
Total pages 8
Language eng
Abstract/Summary Identification and characterisation of the genes involved in melanin pigment formation, together with the study of how their action is influenced by exposure to UV radiation, is providing a molecular understanding of the process of skin photoprotection through tanning. The mechanisms underlying this change in epidermal melanin involve both a transcriptional response of the pigmentation genes and post-translational control of the melanin biosynthetic pathway. UV rays are known to interact with numerous molecules within cells, and among these the photochemical reactions involving lipids and DNA are implicated in modulating melanogenesis. The combination of DNA damage, the formation of diacylglycerol, and the action of the melanocyte stimulating hormone receptor are all likely to be involved in UV-induced tanning.
Keyword Melanocyte
Melanoma
MSHR
P-locus
Skin tanning
Tyrosinase
Q-Index Code E1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Conference Paper
Collection: Institute for Molecular Bioscience - Publications
 
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