A comparison of the transcutaneous kinetics of six commercial formulations of hydrocortisone

Ahlstrom, L.A., Cross, S.E. and Mills, P.C. (2011) A comparison of the transcutaneous kinetics of six commercial formulations of hydrocortisone. Australian Veterinary Practitioner, 41 1: 24-28.

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Author Ahlstrom, L.A.
Cross, S.E.
Mills, P.C.
Title A comparison of the transcutaneous kinetics of six commercial formulations of hydrocortisone
Journal name Australian Veterinary Practitioner   Check publisher's open access policy
ISSN 0310-138X
Publication date 2011-03
Sub-type Article (original research)
Volume 41
Issue 1
Start page 24
End page 28
Total pages 5
Place of publication Australia
Publisher Australian Small Animal Veterinary Association
Collection year 2012
Language eng
Abstract The aim of this study was to compare the penetration of hydrocortisone through canine skin in vitro, when applied from six, commercially available, veterinary or human medical creams containing 0.5% hydrocortisone (HC) or hydrocortisone acetate (HCA). Full thickness skin was mounted in Franz-type diffusion cells and randomly divided for use between treatment groups of different HC or HCA formulations. The amount of HC penetrating the skin in the 30 hours following application of a cream was quantified using HPLC analyses. The rate of transdermal penetration of HC from one cream was 1.7, 1.9, 13.1 and 20.6 times greater than from four others, respectively. This study has shown that the rate of penetration through dog skin can vary greatly from different formulations of the same concentration of drug.
Keyword Placebo-controlled trial
In-vitro penetration
Percutaneous-absorption
Atopic-dermatitis
Canine skin
Vehicle
Dogs
Testosterone
Aceponate
Efficacy
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collections: Official 2012 Collection
School of Medicine Publications
School of Veterinary Science Publications
 
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Created: Tue, 05 Jul 2011, 15:01:57 EST by Ms Lynette Adams on behalf of School of Veterinary Science