A comparison of diagnostic-tests to determine helicobacter-pylori infection

Lin, S.K., Lambert, J.R., Schembri, M., Nicholson, L., Finlay, M., Wong, C. and Coulepis, A. (1992) A comparison of diagnostic-tests to determine helicobacter-pylori infection. Journal of Gastroenterology and Hepatology, 7 2: 203-209. doi:10.1111/j.1440-1746.1992.tb00963.x

Author Lin, S.K.
Lambert, J.R.
Schembri, M.
Nicholson, L.
Finlay, M.
Wong, C.
Coulepis, A.
Title A comparison of diagnostic-tests to determine helicobacter-pylori infection
Journal name Journal of Gastroenterology and Hepatology   Check publisher's open access policy
ISSN 0815-9319
Publication date 1992-04
Sub-type Article (original research)
DOI 10.1111/j.1440-1746.1992.tb00963.x
Volume 7
Issue 2
Start page 203
End page 209
Total pages 7
Place of publication Richmond, VIC, Australia
Publisher Wiley-Blackwell Publishing Asia
Language eng
Formatted abstract
Twenty-five Helicobacter pylori positive and 25 H. pylori negative subjects as defined by culture and phase contrast microscopy of antral biopsy specimens obtained from routine upper endoscopy were studied. Antral biopsies were examined by rapid urease test, phase contrast microscopy, culture and histology. Venous blood was tested for H. pylori specific IgG antibodies by an ELISA technique. Within 7 days of endoscopy the patients also had a[ 14C]-urea breath test. The sensitivity and specificity of the rapid urease test was 92%, the breath test 96% and 100%, histopathology 96% and 91% and serology 96% and 88%, respectively. The [ 14C]-urea breath test performed over 1 h with sampling of subjects at 0, 0.5 and 1 h was an accurate and reliable method. Results expressed as counts per minute of the expired 14CO 2 proved to be a simple method of assessing H. pylori status. A significant correlation between severity of histological antral gastritis and the amount of 14CO 2 expired was observed. This study has shown that the non-invasive 14C-urea breath test and serology are highly sensitive and specific for the diagnosis of H. pylori infection.
Keyword [C-14]-Urea breath test
Diagnostic test
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ
Additional Notes Article first published online: 10 March 2008.

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
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