Bacterial adhesins: Function and structure

Klemm, Per and Schembri, Mark A. (2000) Bacterial adhesins: Function and structure. International Journal of Medical Microbiology, 290 1: 27-35.

Author Klemm, Per
Schembri, Mark A.
Title Bacterial adhesins: Function and structure
Journal name International Journal of Medical Microbiology   Check publisher's open access policy
ISSN 1438-4221
Publication date 2000-03
Sub-type Article (original research)
Volume 290
Issue 1
Start page 27
End page 35
Total pages 9
Place of publication Jena, Germany
Publisher Urban und Fischer
Language eng
Abstract Specific adhesion to host tissue cells is an essential virulence factor of most bacterial pathogens. The fundamental processes that determine bacterial attachment to host tissue surfaces are mediated by microbial adhesins. Host specificity and tissue tropism are characteristics exhibited by different bacteria and are determined (at least in part) by the interaction between adhesins and their complementary receptors on host cell surfaces. A detailed picture of how bacteria are able to target to various receptors is emerging. A large number of bacterial adhesins with individual receptor specificities have been identified. Furthermore, recent research has shown that individual adhesins are prone to rapid microevolution that results in changes in the receptor specificity of individual adhesins. Microbial adhesins are often assembled into complex polymeric organelle structures, however non-organelle adhesins linked to the cell surface as monomers or simple oligomers also exist. This review gives an overview of bacterial adhesins and focuses on some general aspects of their biogenesis and role in bacterial colonization of host cell surfaces and as virulence factors.
Keyword Architecture
Bacterial adhesins
Receptor specificity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
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