A renaissance for the pioneering 16S rRNA gene

Tringe, SG and Hugenholtz, P (2008) A renaissance for the pioneering 16S rRNA gene. Current Opinions in Microbiology, 11 5: 442-446. doi:10.1016/j.mib.2008.09.011

Author Tringe, SG
Hugenholtz, P
Title A renaissance for the pioneering 16S rRNA gene
Journal name Current Opinions in Microbiology   Check publisher's open access policy
ISSN 1369-5274
Publication date 2008-10
Sub-type Article (original research)
DOI 10.1016/j.mib.2008.09.011
Volume 11
Issue 5
Start page 442
End page 446
Total pages 5
Place of publication London, United Kingdom
Publisher Elsevier
Language eng
Abstract Culture-independent molecular surveys using the 16S rRNA gene have become a mainstay for characterizing microbial community structure over the past quarter century. More recently this approach has been overshadowed by metagenomics, which provides a global overview of a community's functional potential rather than just an inventory of its inhabitants. However, the pioneering 16S rRNA gene is making a comeback in its own right thanks to a number of methodological advancements including higher resolution (more sequences), analysis of multiple related samples (e.g. spatial and temporal series) and improved metadata, and use of metadata. The standard conclusion that microbial ecosystems are remarkably complex and diverse is now being replaced by detailed insights into microbial ecology and evolution based only on this one historically important marker gene.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown
Additional Notes Journal issue: Antimicrobials/Genomics

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Chemistry and Molecular Biosciences
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Citation counts: TR Web of Science Citation Count  Cited 161 times in Thomson Reuters Web of Science Article | Citations
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Created: Fri, 24 Jun 2011, 15:24:11 EST by Professor Philip Hugenholtz on behalf of School of Chemistry & Molecular Biosciences