The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos

Wright, Edwina, Hargrave, Murray R., Christiansen, Jeffrey, Cooper, Leanne, Kun, Jutta, Evans, Timothy, Gangadharan, Uma, Greenfield, Andy and Koopman, Peter (1995) The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos. Nature Genetics, 9 1: 15-20. doi:10.1038/ng0195-15


Author Wright, Edwina
Hargrave, Murray R.
Christiansen, Jeffrey
Cooper, Leanne
Kun, Jutta
Evans, Timothy
Gangadharan, Uma
Greenfield, Andy
Koopman, Peter
Title The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos
Formatted title
The Sry-related gene Sox9 is expressed during chondrogenesis in mouse embryos
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 1995-01-01
Sub-type Article (original research)
DOI 10.1038/ng0195-15
Volume 9
Issue 1
Start page 15
End page 20
Total pages 6
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Abstract Mutations in the human SRY-related gene, SOX9, located on chromosome 17, have recently been associated with the sex reversal and skeletal dysmorphology syndrome, campomelic dysplasia. In order to clarify the role of this gene in skeletal development, we have studied the expression of mouse Sox9 during embryogenesis. Sox9 is expressed predominantly in mesenchymal condensations throughout the embryo before and during the deposition of cartilage, consistent with a primary role in skeletal formation. Interspecific backcross mapping has localized mouse Sox9 to distal chromosome 11. The expression pattern and chromosomal location of Sox9 suggest that it may be the gene defective in the mouse skeletal mutant Tail-short, a potential animal model for campomelic dysplasia.
Keyword Transcription factor
Campomelic syndrome
Sex reversal
Hmg box
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Unknown

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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