Fresh and cryopreserved ovarian tissue samples from donors with lymphoma transmit the cancer to graft recipients

Shaw, J., Bowles, J., Koopman, P., Wood, E. C. and Trounson, A. O. (1996) Fresh and cryopreserved ovarian tissue samples from donors with lymphoma transmit the cancer to graft recipients. Human Reproduction, 11 8: 1668-1673.

Author Shaw, J.
Bowles, J.
Koopman, P.
Wood, E. C.
Trounson, A. O.
Title Fresh and cryopreserved ovarian tissue samples from donors with lymphoma transmit the cancer to graft recipients
Journal name Human Reproduction   Check publisher's open access policy
ISSN 0268-1161
1460-2350
Publication date 1996-08
Sub-type Article (original research)
Volume 11
Issue 8
Start page 1668
End page 1673
Total pages 6
Place of publication Oxford, United Kingdom
Publisher Oxford University Press
Language eng
Abstract Girls and young women who require ova riectomy or cancer therapy may consider having their own eggs, embryos or ovarian tissue stored (cryopreserved) for their own future use. Ovarian tissue is simple to collect and contains large numbers of germ cells. Transplantation of fresh and frozen-thawed ovarian tissue in healthy sheep and mice has resulted in normal live young. Similar techniques may be effective in the human but it is unclear whether ovarian tissue cryopreservation and grafting is suitable for ovaries from individuals with cancer or infections. If cancer cells mere present in an ovary at the time of collection and survived cryopreservation and grafting they could establish cancer in the recipient. We therefore performed ovarian cryopreservation and transplantation trials using a mouse lymphoma model. This established that the lymphoma was transmitted by grafts of both fresh and frozen ovarian tissue. The normal healthy recipient mice died 9-43 days after receiving a small piece (1 mm3) of ovarian tissue from a donor with lymphoma. We conclude that ovarian tissue which is collected, cryopreserved anti grafted while it contains cancer cells has the potential to spread the cancer to the graft recipient.
Keyword Cancer
Cryopreservation
Mouse
Ovary
Transplantation
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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