Cell-autonomous action of the testis-determining gene: Sertoli cells are exclusively XY in XX ⇆ XY chimaeric mouse testes

Burgoyne, P. S., Buehr, M., Koopman, P., Rossant, J. and McLaren, A. (1988) Cell-autonomous action of the testis-determining gene: Sertoli cells are exclusively XY in XX ⇆ XY chimaeric mouse testes. Development, 102 2: 443-450.

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Author Burgoyne, P. S.
Buehr, M.
Koopman, P.
Rossant, J.
McLaren, A.
Title Cell-autonomous action of the testis-determining gene: Sertoli cells are exclusively XY in XX ⇆ XY chimaeric mouse testes
Journal name Development   Check publisher's open access policy
ISSN 0950-1991
1477-9129
Publication date 1988-02-01
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 102
Issue 2
Start page 443
End page 450
Total pages 8
Place of publication Cambridge, United Kingdom
Publisher The Company of Biologists
Language eng
Abstract The distribution of XX and XY cells in XX ⇆ XY chimaeric mouse testes was analysed by enzyme marker analysis of separated testicular tissues and by in situ DNA marker analysis of air-dried testicular cells and testis sections. XX cells contributed to the Leydig cells, the peritubular cells and the vascularized connective tissue of the tunica albuginea. The Sertoli cells, on the other hand, appeared to be exclusively XY. These results indicate that during the development of the testis, Sertoli cell differentiation is triggered by cell-autonomous activity of the Y chromosomal testis-determining gene Tdy. Subsequent steps in testis differentiation may be a consequence of Sertoli cell activity.
Keyword Testis determination
XX ⇆ XY chimeras
Sertoli cells
Leydig cells
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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