Zfy gene expression patterns are not compatible with a primary role in mouse sex determination

Koopman, Peter, Gubbay, John, Collignon, Jerome and Lovell-Badge, Robin (1989) Zfy gene expression patterns are not compatible with a primary role in mouse sex determination. Nature, 342 6252: 940-942. doi:10.1038/342940a0


Author Koopman, Peter
Gubbay, John
Collignon, Jerome
Lovell-Badge, Robin
Title Zfy gene expression patterns are not compatible with a primary role in mouse sex determination
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
1476-4687
Publication date 1989-12-01
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1038/342940a0
Volume 342
Issue 6252
Start page 940
End page 942
Total pages 3
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Formatted abstract
The Y chromosome determines maleness in mammals. A Y chromosome-linked gene diverts the indifferent embryonic gonad from the default ovarian pathway in favour of testis differentiation, initiating male development. Study of this basic developmental switch requires the isolation of the testis-determining gene, termed TDF in humans and Tdy in mice. ZFY, a candidate gene for TDF, potentially encodes a zinc-finger protein, and has two Y-linked homologues, Zfy-1 and Zfy-2, in mice. Although ZFY, Zfy-1 and Zfy-2 seem to map to the sex-determining regions of the human and mouse Y chromosomes, there is no direct evidence that these genes are involved in testis determination. We report here that Zfy-1 but not Zfy-2 is expressed in differentiating embryonic mouse testes. Neither gene, however, is expressed in W(e)/W(e) mutant embryonic testes which lack germ cells. These observations exclude both Zfy-1 and Zfy-2 as candidates for the mouse testis-determining gene.
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: Institute for Molecular Bioscience - Publications
 
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