Normal structure and expression of Zfy genes in XY female mice mutant in Tdy

Gubbay, John, Koopman, Peter, Collignon, Jerome and Burgoyne, Paul (1990) Normal structure and expression of Zfy genes in XY female mice mutant in Tdy. Development, 109 3: 647-653.

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Author Gubbay, John
Koopman, Peter
Collignon, Jerome
Burgoyne, Paul
Title Normal structure and expression of Zfy genes in XY female mice mutant in Tdy
Journal name Development   Check publisher's open access policy
ISSN 0950-1991
1477-9129
Publication date 1990-07
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 109
Issue 3
Start page 647
End page 653
Total pages 7
Place of publication Cambridge, United Kingdom
Publisher The Company of Biologists
Language eng
Abstract Zfy-1 and Zfy-2 are candidate genes for Tdy, the testis-determining gene in mice. We have analysed these genes in a line of XY female mice that have been shown to be mutated in Tdy. We have used Southern blot analysis to show that the Zfy genes have not undergone any major structural alterations, and have also demonstrated that both genes are transcribed normally from the mutant Y chromosome (Y) in both adult XYY testis and XY female embryonic gonads. The fact that these genes show a normal structure and expression pattern in mice with a Y chromosome known to carry a mutation in Tdy and that mutant embryos develop into females despite Zfy-1 expression, strongly supports other recent evidence that Zfy genes are not directly involved in primary testis determination.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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