Male development of chromosomally female mice transgenic for Sry

Koopman, Peter, Gubbay, John, Vivian, Nigel, Goodfellow, Peter and Lovell Badge, Robin (1991) Male development of chromosomally female mice transgenic for Sry. Nature, 351 6322: 117-121. doi:10.1038/351117a0


Author Koopman, Peter
Gubbay, John
Vivian, Nigel
Goodfellow, Peter
Lovell Badge, Robin
Title Male development of chromosomally female mice transgenic for Sry
Journal name Nature   Check publisher's open access policy
ISSN 0028-0836
1476-4687
Publication date 1991-05
Sub-type Article (original research)
DOI 10.1038/351117a0
Volume 351
Issue 6322
Start page 117
End page 121
Total pages 5
Place of publication Hamps, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.
Keyword Testis-determining gene
Sex-reversed mice
Y-chromosome
Mouse
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
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