Expression of a linear Sry transcript in the mouse genital ridge

Jeske, Yvette W. A., Bowles, Josephine, Greenfield, Andy and Koopman, Peter (1995) Expression of a linear Sry transcript in the mouse genital ridge. Nature Genetics, 10 4: 480-482. doi:10.1038/ng0895-480


Author Jeske, Yvette W. A.
Bowles, Josephine
Greenfield, Andy
Koopman, Peter
Title Expression of a linear Sry transcript in the mouse genital ridge
Journal name Nature Genetics   Check publisher's open access policy
ISSN 1061-4036
1546-1718
Publication date 1995-08
Sub-type Letter to editor, brief commentary or brief communication
DOI 10.1038/ng0895-480
Volume 10
Issue 4
Start page 480
End page 482
Total pages 3
Place of publication New York, NY, United States
Publisher Nature Publishing Group
Language eng
Abstract Sry is the Y-chromosomal gene that is pivotal in the determination of sex in mammals, however the structure of the Sry transcript produced in the embryo has not been determined. We show here that the transcript expressed in the developing mouse gonad at the sex determining stage of development is linear, polyadenylated and encoded by a single exon, in contrast to the circular, apparently untranslated transcript produced in adult testes. The linear transcript was not detected in any other fetal tissue nor in any adult tissue tested, and was expressed only in the genital ridge portion of the urogenital ridge. The spatial and temporal profile of Sry expression suggests that its role in the mouse fetus is limited to initiating Sertoli cell development during testis determination.
Keyword Testis-determining gene
Sex-determining region
Mice
Differentiation
Locus
Cells
Xy
Q-Index Code CX
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Letter to editor, brief commentary or brief communication
Collection: Institute for Molecular Bioscience - Publications
 
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