Spinal cord metabolism and muscle water diffusion in whiplash

Elliott, J. M., Pedler, A.R,., Cowin, G., Sterling, M. M. and McMahon, K. (2012) Spinal cord metabolism and muscle water diffusion in whiplash. Spinal Cord, 50 6: 474-476. doi:10.1038/sc.2011.17

Author Elliott, J. M.
Pedler, A.R,.
Cowin, G.
Sterling, M. M.
McMahon, K.
Title Spinal cord metabolism and muscle water diffusion in whiplash
Journal name Spinal Cord   Check publisher's open access policy
ISSN 1362-4393
Publication date 2012-06
Year available 2011
Sub-type Article (original research)
DOI 10.1038/sc.2011.17
Volume 50
Issue 6
Start page 474
End page 476
Total pages 3
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Collection year 2012
Language eng
Formatted abstract
Study design:
Case series.

To quantify spinal cord metabolites and neck muscle fast and slow water diffusion in a small sample of patients with chronic whiplash and healthy controls.


Brisbane, Queensland, Australia.

In five subjects with chronic whiplash and seven controls, we performed magnetic resonance spectroscopy (MRS) of the cervical spinal cord and diffusion-weighted imaging (DWI) of the cervical multifidus muscle.

Significant reductions in N-acetylaspartate/creatine ratios were found in subjects with chronic whiplash when compared with healthy controls (P=0.02). Significantly higher fast apparent diffusion coefficients (ADCs) were found in chronic whiplash when compared with the healthy controls (P=0.01). There was no difference in slow ADCs between the two groups (P=0.3).

The potential value of MRS and DWI to quantify the presence of neuromuscular degeneration as a potential mechanism underlying chronic whiplash is recognized. Larger-scaled prospective studies are warranted and required
Keyword Whiplash
MR spectroscopy
Diffusion-weighted imaging
Q-Index Code C1
Q-Index Status Confirmed Code
Institutional Status UQ
Additional Notes This publication is for The Centre of National Research on Disability and Rehabilitation Medicine (CONROD). Published under 'Case Report'. Published online 8 March 2011.

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Created: Thu, 23 Jun 2011, 09:18:32 EST by Chesne McGrath on behalf of Medicine - Royal Brisbane and Women's Hospital