Ethnic differences in lipid metabolism in two groups of obese South African women

Punyadeera, C., van der Merwe, M. T., Crowther, N. J., Toman, M., Schlaphoff, G. P. and Gray, I. P. (2001) Ethnic differences in lipid metabolism in two groups of obese South African women. Journal of Lipid Research, 42 5: 760-767.

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Author Punyadeera, C.
van der Merwe, M. T.
Crowther, N. J.
Toman, M.
Schlaphoff, G. P.
Gray, I. P.
Title Ethnic differences in lipid metabolism in two groups of obese South African women
Journal name Journal of Lipid Research   Check publisher's open access policy
ISSN 0022-2275
Publication date 2001-05
Sub-type Article (original research)
Open Access Status File (Publisher version)
Volume 42
Issue 5
Start page 760
End page 767
Total pages 8
Place of publication Bethesda, MD, United States
Publisher American Society for Biochemistry and Molecular Biology
Language eng
Formatted abstract
There is a higher prevalence of ischemic heart disease (IHD) in South African white than black women. The objective of this study was to determine biochemical explanations for this prevalence. The study group contained 15 obese black women (OBW) and 14 obese white women (OWW), all premenopausal, who were examined after an overnight fast. Anthropometric measurements and blood concentrations of glucose, non-esterified fatty acids (NEFAs), catecholamines, plasminogen activator inhibitor-1, C-peptide, proinsulin, lipograms, cortisol, growth hormone, and post-heparin lipoprotein lipase activity were measured during an oral glucose tolerance test (OGTT). Body composition was measured using bioelectrical impedance analysis, and subcutaneous and visceral fat mass were assessed with CT-scans. Visceral fat area was higher in OWW (139.7 ± 10.7 cm 2) than in OBW (72.3 ± 3.9 cm 2) (P < 0.01), as were fasting and 3 h triglyceride concentrations (P < 0.05 for all). OWW also had higher NEFA levels than OBW at 3 and 4 h compared with OBW (P < 0.05 for both). Fasting cortisol (266 ± 24 vs. 197 ± 19 nmol/1; P < 0.05) was higher in OWW than in OBW. These data demonstrate that OWW have higher visceral fat mass than OBW, which may lead to a more atherogenic fasting and postprandial lipid profile. The higher cortisol levels of the OWW may promote visceral fat deposition.
Keyword Cortisol
Fasting and postprandial triglyceride levels
Lipoprotein lipase
Nonesterified fatty acids
Visceral abdominal adiposity
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
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