Metabolic response to a mixed meal in obese and lean women from two South African populations

Punyadeera, Chamindie, Crowther, Nigel J., van der Merwe, Maria-Terésa, Toman, Marketa, Immelman, Andrew Ronnie, Schlaphoff, Glen P. and Gray, Ian Peter (2002) Metabolic response to a mixed meal in obese and lean women from two South African populations. Obesity Research, 10 12: 1207-1216. doi:10.1038/oby.2002.165

Author Punyadeera, Chamindie
Crowther, Nigel J.
van der Merwe, Maria-Terésa
Toman, Marketa
Immelman, Andrew Ronnie
Schlaphoff, Glen P.
Gray, Ian Peter
Title Metabolic response to a mixed meal in obese and lean women from two South African populations
Journal name Obesity Research   Check publisher's open access policy
ISSN 1071-7323
Publication date 2002-12
Sub-type Article (original research)
DOI 10.1038/oby.2002.165
Volume 10
Issue 12
Start page 1207
End page 1216
Total pages 10
Place of publication Hoboken, NJ, United States
Publisher Wiley-Blackwell
Language eng
Formatted abstract
Objective: Lower lipid and insulin levels are found during a glucose-tolerance test in obese black than obese white South African women. Therefore, β-cell function and lipid metabolism were compared in these populations during a mixed meal.

Research Methods and Procedures: Blood concentrations of glucose, free fatty acids (FFAs), insulin, lipograms, and in vivo FFA oxidation were determined at fasting and for 7 hours after oral administration of a mixed emulsion containing glucose-casein-sucrose-lipid and [1- 13C] palmitic acid in 8 lean black women (LBW), 10 obese black women (OBW), 9 lean white women (LWW), and 10 obese white women (OWW). Subcutaneous and visceral fat mass was assessed by computerized tomography.

Results: Visceral fat area was higher in OWW (152.7 ± 17.0 cm 2) than OBW (80.0 ± 6.7 cm 2; p < 0.01). In OBW, 30-minute insulin levels were higher (604.3 ± 117.6 pM) than OWW (311.0 ± 42.9 pM; p < 0.05). Total triglyceride was higher in OWW (706.7 ± 96.0 mM × 7 hours) than OBW (465.7 ± 48.2 mM × 7 hours; p < 0.05) and correlated with visceral fat area (β = 0.38, p = 0.05). Palmitate oxidation was higher in lean than obese women in both ethnic groups and correlated negatively with fat mass (β = -0.58, p < 0.005).

Discussion: The higher 30-minute insulin response in OBW may reflect a higher insulinotropic effect of FFAs or glucose. The elevated triglyceride level of OWW may be due to their higher visceral fat mass and possibly reduced clearance by adipose tissue.
Keyword Visceral obesity
In vivo lipid oxidation
Triglyceride metabolism
Insulin secretion
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Australian Institute for Bioengineering and Nanotechnology Publications
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 8 times in Thomson Reuters Web of Science Article | Citations
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Wed, 22 Jun 2011, 16:15:55 EST by System User on behalf of Aust Institute for Bioengineering & Nanotechnology