Oestrogen-modulated gene expression in the human endometrium

Punyadeera, C., Dassen, H., Klomp, J., Dunselman, G., Kamps, R., Dijcks, F., Ederveen, A., de Goeij, A. and Groothuis, P. (2005) Oestrogen-modulated gene expression in the human endometrium. Cellular and Molecular Life Sciences, 62 2: 239-250. doi:10.1007/s00018-004-4435-y

Author Punyadeera, C.
Dassen, H.
Klomp, J.
Dunselman, G.
Kamps, R.
Dijcks, F.
Ederveen, A.
de Goeij, A.
Groothuis, P.
Title Oestrogen-modulated gene expression in the human endometrium
Journal name Cellular and Molecular Life Sciences   Check publisher's open access policy
ISSN 1420-682X
Publication date 2005-01
Sub-type Article (original research)
DOI 10.1007/s00018-004-4435-y
Volume 62
Issue 2
Start page 239
End page 250
Total pages 12
Place of publication Basel, Switzerland
Publisher Birkhaeuser Verlag
Language eng
Formatted abstract
To identify key regulatory mechanisms in the growth and development of the human endometrium, microarray analysis was performed on uncultured human endometrium collected during menstruation (M) and the late-proliferative (LATE-P)-phase of the menstrual cycle, as well as after 24 h incubation in the presence of oestradiol (17ß-E2). We demonstrate the expression of novel gene transcripts in the human endometrium. i.e. mucin-9, novel oestrogen-responsive gene transcripts, i.e. gelsolin and flotillin-1, and genes known to be expressed in human endometrium but not yet shown to be oestrogen responsive, i.e. connexin-37 and TFF1/pS2. Genes reported to be expressed during the implantation window and implicated in progesterone action, i.e. secretoglobin family 2A, member 2 (mammaglobin) and homeobox-containing proteins, were up-regulated in uncultured LATE-P-phase endometrium compared to M-phase endometrium. Some gene transcripts are regulated directly by 17ß-E2 alone, others are influenced by the in vivo environment as well. These observations emphasise that the regulation of endometrium maturation by oestrogen entails more then just stimulation of cell proliferation.
Keyword Steroid hormones
Cell differentiation
Extracellular matrix remodelling
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
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