Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP

Suraweera, Nirosha, Latchford, Andrew, McCart, Amy, Rogers, Pauline, Spain, Sarah, Sieber, Oliver, Phillips, Robin, Tomlinson, Ian and Silver, Andrew (2007) Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP. Journal of Medical Genetics, 44 8: 541-544. doi:10.1136/jmg.2007.049965


Author Suraweera, Nirosha
Latchford, Andrew
McCart, Amy
Rogers, Pauline
Spain, Sarah
Sieber, Oliver
Phillips, Robin
Tomlinson, Ian
Silver, Andrew
Title Pregnancy does not influence colonic polyp multiplicity but may modulate upper gastrointestinal disease in patients with FAP
Journal name Journal of Medical Genetics   Check publisher's open access policy
ISSN 0022-2593
1468-6244
Publication date 2007-08
Sub-type Article (original research)
DOI 10.1136/jmg.2007.049965
Volume 44
Issue 8
Start page 541
End page 544
Total pages 4
Place of publication London, United Kingdom
Publisher BMJ Group
Language eng
Formatted abstract
Background: Reproductive factors have been shown by epidemiology studies to alter colorectal cancer risk in women. Familial adenomatous polyposis (FAP) patients carry a germline adenomatous polyposis coli (APC) mutation predisposing to multiple  adenoma formation in the intestine. The Min mouse provides a good model of FAP, and we recently reported a significant increase in intestinal tumour multiplicity in a recombinant line of mice following pregnancy.

Aim: We considered whether reproduction modulates intestinal tract disease in a large cohort of female patients with FAP (n = 180).

Results: Multiple regression analysis showed that the number of colonic polyps observed was not related to the person’s pregnancy status nor the position of their APC germline mutation. The proportion of women attaining a high Spigelman stage (3 or 4) was unrelated to having a pregnancy prior to attaining the maximum Spigelman stage (p = 0.6). On the other hand, having a pregnancy significantly increased the proportion of women that attained the highest Spigelman stage when their APC germline mutation occurred within the mutation cluster region or at or after codon 1020 (50%, 6/12, p = 0.005 and 42%, 13/31, p = 0.006, respectively; multivariable logistic regression).

Conclusion: Our data suggest that reproduction may influence disease severity in the upper gastrointestinal tract in patients with FAP.
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
 
Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in Thomson Reuters Web of Science Article
Scopus Citation Count Cited 0 times in Scopus Article
Google Scholar Search Google Scholar
Created: Wed, 22 Jun 2011, 15:12:34 EST by System User on behalf of Institute for Molecular Bioscience