Apc mice: Models, modifiers and mutants

McCart, Amy E., Vickaryous, Nicola K. and Silver, Andrew (2008) Apc mice: Models, modifiers and mutants. Pathology Research and Practice, 204 7: 479-490. doi:10.1016/j.prp.2008.03.004

Author McCart, Amy E.
Vickaryous, Nicola K.
Silver, Andrew
Title Apc mice: Models, modifiers and mutants
Journal name Pathology Research and Practice   Check publisher's open access policy
ISSN 0344-0338
Publication date 2008
Sub-type Article (original research)
DOI 10.1016/j.prp.2008.03.004
Volume 204
Issue 7
Start page 479
End page 490
Total pages 12
Place of publication Jena, Germany
Publisher Urban und Fischer Verlag
Language eng
Abstract The mouse provides an excellent in vivo system with which to model human diseases and to test therapies. Mutations in the Adenomatous polyposis coli (APC) gene are required to initiate familial adenomatous polyposis (FAP) and are also important in sporadic colorectal cancer tumorigenesis. The (multiple intestinal neoplasia Min) mouse contains a point mutation in the Apc gene, develops numerous adenomas and was the first model used to study the involvement of the Apc gene in intestinal tumorigenesis. The model has provided examples of modifying loci (called Modifiers of Min: Mom) in mice, demonstrating the principle of genetic modulation of disease severity. A spectrum of Apc mutant mice has since been developed, each with defining characteristics, some more able to accurately model human polyposis and colon cancer. We will focus our review on Apc mutant mouse models, the advent of models with concurrent or compound mutations and the importance of genetic background when modeling polyposis and cancer. Brief consideration will be given to the use of these models in drug testing.
Keyword Apc
Colorectal cancer
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: Institute for Molecular Bioscience - Publications
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