Loss of heterozygosity in ductal carcinoma in situ of the breast

Stratton, M. R., Collins, N., Lakhani, S. R. and Sloane, J. P. (1995) Loss of heterozygosity in ductal carcinoma in situ of the breast. Journal of Pathology, 175 2: 195-201. doi:10.1002/path.1711750207


Author Stratton, M. R.
Collins, N.
Lakhani, S. R.
Sloane, J. P.
Title Loss of heterozygosity in ductal carcinoma in situ of the breast
Formatted title
Loss of heterozygosity in ductal carcinoma in situ of the breast
Journal name Journal of Pathology   Check publisher's open access policy
ISSN 0022-3417
1096-9896
Publication date 1995-02
Sub-type Article (original research)
DOI 10.1002/path.1711750207
Volume 175
Issue 2
Start page 195
End page 201
Total pages 7
Place of publication West Sussex, United Kingdom
Publisher John Wiley & Sons
Language eng
Formatted abstract
Loss of heterozygosity (LOH) at loci reported to show allele loss in invasive breast cancers was examined in ductal in situ carcinomas of the breast using polymorphic short tandem repeats and the polymerase chain reaction (PCR). LOH was detected at all loci examined in at least 11 per cent of the samples examined. The proportion of cases of in situ carcinoma showing LOH at these loci was similar to that previously reported in invasive cancers. Cases of pure in situ cancer without an invasive component exhibited an overall lower frequency of allele loss. LOH at more than one locus was observed in some intraductal cancers. In a small number of cases, LOH was present in the invasive but not in the intraductal component of the tumour, suggesting that mutation at the locus concerned was associated with development of invasive behaviour.
Keyword Breast cancer
Ductal carcinoma in situ
Loss of heterozygosity
Familial breast
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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