Malignant myoepithelioma (Myoepithelial carcinoma) of the breast - a detailed cytokeratin study

Lakhani, S. R., Ohare, M. J., Winehouse, J., Gazet, J. C. and Sloane, J. P. (1995) Malignant myoepithelioma (Myoepithelial carcinoma) of the breast - a detailed cytokeratin study. Journal of Clinical Pathology, 48 2: 164-167. doi:10.1136/jcp.48.2.164

Author Lakhani, S. R.
Ohare, M. J.
Winehouse, J.
Gazet, J. C.
Sloane, J. P.
Title Malignant myoepithelioma (Myoepithelial carcinoma) of the breast - a detailed cytokeratin study
Journal name Journal of Clinical Pathology   Check publisher's open access policy
ISSN 0021-9746
Publication date 1995-02
Sub-type Article (original research)
DOI 10.1136/jcp.48.2.164
Volume 48
Issue 2
Start page 164
End page 167
Total pages 4
Place of publication London, United Kingdom
Publisher B M J Group
Language eng
Formatted abstract
AIMS--To study the expression of a range of cytokeratins by malignant myoepithelioma of the breast.
METHODS--Immunophenotyping was carried out using a panel of antibodies on paraffin wax embedded and frozen material using immunohistochemistry and double-labelled immunofluorescence. Electron microscopy was also performed.
RESULTS--The tumour cells were positive for CAM 5.2, actin, vimentin, and cytokeratin 14 and negative for cytokeratins 18 and 19. Electron microscopy showed well formed desmosomes and hemidesmosomes together with pinocytic vesicles, plentiful rough endoplasmic reticulum and 6 nM microfilaments with focal densities.
CONCLUSIONS--The pattern of cytokeratin expression provides further evidence that tumours with a specific myoepithelial phenotype occur rarely in the breast.
Keyword Malignant Myoepithelioma
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
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