Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13

Cleton-Jansen, A. -M., Collins, N., Lakhani, S. R., Weissenbach, J., Devilee, P., Cornelisse, C. J. and Stratton, M. R. (1995) Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13. British Journal of Cancer, 72 5: 1241-1244. doi:10.1038/bjc.1995.493


Author Cleton-Jansen, A. -M.
Collins, N.
Lakhani, S. R.
Weissenbach, J.
Devilee, P.
Cornelisse, C. J.
Stratton, M. R.
Title Loss of heterozygosity in sporadic breast tumours at the BRCA2 locus on chromosome 13q12-q13
Journal name British Journal of Cancer   Check publisher's open access policy
ISSN 0007-0920
1532-1827
Publication date 1995-11
Sub-type Article (original research)
DOI 10.1038/bjc.1995.493
Open Access Status DOI
Volume 72
Issue 5
Start page 1241
End page 1244
Total pages 4
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Loss of heterozygosity (LOH) on chromosome 13 occurs on 25-30% of breast tumours. This may reflect the inactivation of the retinoblastoma susceptibility gene RB1. However, recently another candidate tumour-suppressor gene has been identified on chromosome 13 by linkage analysis, the breast cancer susceptibility gene BRCA2. To investigate the involvement of BRCA2 in sporadic breast cancer 200 breast tumours were tested for LOH on chromosome band 13q12-q14, using 11 highly polymorphic microsatellite markers. LOH was found in 65 tumours, which all showed simultaneously loss of BRCA2 and RB1. Of 12 breast tumour cell lines tested with polymorphic microsatellite markers, seven showed a contiguous region of homozygosity on 13q12-q14, suggesting LOH in the tumour from which the cell line had been derived. One cell line showed homozygosity in the BRCA2 region and heterozygosity at RB1. This is the only indication that BRCA2 is a distinct target for LOH on chromosome 13 in addition to RB1.
Keyword BRCA2
RB1
Loss of heterozygosity
Breast cancer
Tumor-suppressor gene
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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