The cylindromatosis gene (cyld1) on chromosome 16q may be the only tumour suppressor gene involved in the development of cylindromas

Chapman, P., Lakhani, S. R. and Burn, J. (1996) The cylindromatosis gene (cyld1) on chromosome 16q may be the only tumour suppressor gene involved in the development of cylindromas. Oncogene, 12 6: 1375-1377.

Author Chapman, P.
Lakhani, S. R.
Burn, J.
Title The cylindromatosis gene (cyld1) on chromosome 16q may be the only tumour suppressor gene involved in the development of cylindromas
Journal name Oncogene   Check publisher's open access policy
ISSN 0950-9232
1476-5594
Publication date 1996-03
Sub-type Article (original research)
Volume 12
Issue 6
Start page 1375
End page 1377
Total pages 3
Place of publication London, United Kingdom
Publisher Nature Publishing Group
Language eng
Abstract Hereditary cylindromatosis is a rare autosomal dominant disease characterised by the development of multiple benign neoplasms of the skin. We recently localised the gene responsible for this disease (cyld1) to chromosome 16q12-q13 and provided evidence that it is a tumour suppressor gene. We have now examined polymorphic markers on every chromosome, some of which are close to known tumour suppressor genes, in 25 tumours from 4 individuals with familial cylindromatosis. No loss of heterozygosity (LOH) was detected other than at loci on chromosome 16q. This observation suggests that the cyld1 gene may be the only tumour suppressor gene implicated in the development of cylindromas. We have also demonstrated LOH using markers on chromosome 16q in 8/14 (57%) sporadic cylindromas, indicating that the cyld1 gene is likely to be involved in the genesis of both familial and sporadic cylindromas.
Keyword Cylindroma
Cylindromatosis
Tumour suppressor gene
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Article (original research)
Collection: School of Medicine Publications
 
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