The transition from hyperplasia to invasive carcinoma of the breast

Lakhani, Sunil R. (1999) The transition from hyperplasia to invasive carcinoma of the breast. Journal of Pathology, 187 3: 272-278. doi:10.1002/(SICI)1096-9896(199902)187:3<272::AID-PATH265>3.0.CO;2-2


Author Lakhani, Sunil R.
Title The transition from hyperplasia to invasive carcinoma of the breast
Journal name Journal of Pathology   Check publisher's open access policy
ISSN 0022-3417
1096-9896
Publication date 1999-02
Sub-type Critical review of research, literature review, critical commentary
DOI 10.1002/(SICI)1096-9896(199902)187:3<272::AID-PATH265>3.0.CO;2-2
Volume 187
Issue 3
Start page 272
End page 278
Total pages 7
Place of publication West Sussex, United Kingdom
Publisher John Wiley and Sons
Language eng
Abstract The multistep model of carcinogenesis in the breast suggests a transition from normal epithelium to invasive carcinoma via non-atypical and atypical hyperplasia and in situ carcinoma. Within the breast, these proliferations are heterogeneous in their cytological and architectural characteristics. This review considers the evidence supporting a precursor role for these preinvasive lesions.
Keyword Breast
Preinvasive lesions
Molecular genetics
Multistep model
Loss of heterozygosity
Comparative genomic hybridization
Q-Index Code C1
Q-Index Status Provisional Code
Institutional Status Non-UQ

Document type: Journal Article
Sub-type: Critical review of research, literature review, critical commentary
Collection: School of Medicine Publications
 
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